RESUMO
Transdermal patches have become a widely used approach for painless delivery of drugs. One major current limitation of these systems remains the restricted skin permeation of proteins and peptides as exemplified by insulin, necessitating different considerations for their successful transdermal delivery. We present a novel patch design based on the integration of nano-engineered heating elements on polyimide substrates for electrothermal transdermal therapy. The results reveal that tuning of the electrical resistivity of an array of gold nanoholes, patterned on polyimide, facilitates a fast-responding electrothermal skin patch, while post-coating with reduced graphene oxide offers capabilities for drug encapsulation, like insulin. Application of insulin-loaded patches to the skin of mice resulted in blood glucose regulation within minutes. While demonstrated for insulin, the skin patches might be well adapted to other low and high molecular weight therapeutic drugs, enabling on-demand electrothermal transdermal delivery.
Assuntos
Sistemas de Liberação de Medicamentos/métodos , Insulina Regular Humana/administração & dosagem , Adesivo Transdérmico , Dispositivos Eletrônicos Vestíveis , Administração Cutânea , Animais , Sistemas de Liberação de Medicamentos/instrumentação , Liberação Controlada de Fármacos , Ouro/química , Grafite/química , Camundongos , NanoporosRESUMO
La infección por citomegalovirus (CMV) es una causa frecuente de complicaciones en pacientes inmunodeprimidos. En huéspedes sanos, la infección por CMV cursa generalmente de forma asintomática. A continuación se presenta el caso de un paciente de 3 meses de edad inmunocompetente, en el que se desarrolló un cuadro de diarrea grave que precisó nutrición parenteral. El cuadro se resolvió sin secuelas tras tratamiento con ganciclovir (AU)
Cytomegalovirus infection is a frequent cause of complications in immunodeficient patients. In healthy hosts, cytomegalovirus infection is usually asymptomatic. We describe a case of a 3 month old immunocompetent boy who suffered from protracted diarrhoea that required parenteral nutrition. After treatment with ganciclovir he recovered without any after effects (AU)
Assuntos
Humanos , Masculino , Lactente , Infecções por Citomegalovirus/complicações , Diarreia Infantil/etiologia , Infecções por Citomegalovirus/congênito , Citomegalovirus/patogenicidade , Diarreia Infantil/terapia , Nutrição ParenteralRESUMO
Cytomegalovirus infection is a frequent cause of complications in immunodeficient patients. In healthy hosts, cytomegalovirus infection is usually asymptomatic. We describe a case of a 3 month old immunocompetent boy who suffered from protracted diarrhoea that required parenteral nutrition. After treatment with ganciclovir he recovered without any after effects.
Assuntos
Infecções por Citomegalovirus/complicações , Diarreia Infantil/etiologia , Humanos , Imunocompetência , Lactente , MasculinoRESUMO
BACKGROUND: The outcomes of lung transplantation (LT) are well known in developed countries, but not in Latin America. Our objective was to report the LT experience at a single center in Argentina. METHODS: From June 1994 to February 2003, the 54 LT that were performed included 36 single-lung transplants SLT (45.5%) and 18 double-lung transplants (DSLT) (22.7%). Indications for SLT (n = 36) were emphysema (n = 23) and pulmonary fibrosis (n = 13); for DSLT (n = 18), bronchiectasis (n = 8), cystic fibrosis (n = 8), pulmonary emphysema (n = 1), and bronchiolitis obliterans syndrome caused by graft-versus-host disease after bone-marrow transplantation (n = 1). A univariate analysis, chi-square test with Yates' correction was used for qualitative variables; Wilcoxon-Mann-Whitney test, for quantitative and ordinal variables. Survivals were estimated by the Kaplan-Meier method. RESULTS: In-hospital mortality (HM) was 21.1%. Among SLT, early death was due to sepsis in six patients and by ischemia-reperfusion injury (IRI) and acute rejection in other two. In DSLT, two patients died due to IRI and one, sepsis. The overall estimated survival rates at 1, 2, and 4 years were 70.1% +/- 6.5%, 54.3% +/- 7.2%, and 44.3% +/- 7.9%, respectively. The median overall survival was 26.5 (10 to 34) months. When HM was excluded, survival at 4 years was 51.3% +/- 8.7%. The estimated survival at 3 years was 43.3% +/- 9.3% for SLT and 58.7% +/- 13% for DSLT (P = 6). Survival differences according to the baseline diagnosis were not significant (P =.6). Median follow-up time (percentiles 25 to 75) was 16 (2 to 27) months. CONCLUSIONS: Our LT program shows similar results to those reported by the International Society for Heart and Lung Transplantation for developed countries.
Assuntos
Transplante de Pulmão/estatística & dados numéricos , Argentina , Enfisema/cirurgia , Humanos , Transplante de Pulmão/mortalidade , Preservação de Órgãos/métodos , Fibrose Pulmonar/cirurgia , Estudos Retrospectivos , Análise de SobrevidaRESUMO
El número de pacientes que se incluyen en programas de transplante pulmonar es creciente y su sobrevida en lista de espera depende de la posibilidad de acceder a un TxP así como de la progresión de la enfermedad de base. El objetivo de este trabajo es analizar la evolución y sobrevida de los pacientes con enfermedad respiratoria avanzada (ERA) evaluados para trasplante uni y bipulmonar
Assuntos
Adulto , Transplante de Pulmão , Pneumologia , Estudos Retrospectivos , TransplantesRESUMO
El número de pacientes que se incluyen en programas de transplante pulmonar es creciente y su sobrevida en lista de espera depende de la posibilidad de acceder a un TxP así como de la progresión de la enfermedad de base. El objetivo de este trabajo es analizar la evolución y sobrevida de los pacientes con enfermedad respiratoria avanzada (ERA) evaluados para trasplante uni y bipulmonar
Assuntos
Adulto , Transplantes , Transplante de Pulmão , Pneumologia , Estudos RetrospectivosRESUMO
Presentamos una paciente con asociacion VATER y seudohermafroditismo femenino (SHF) probablemente "no adrenal". Se describen 6 pacientes con estas caracteristicas referidas en la literatura (tabla 1).Sobre la base del clasico concepto en Embiologia de Campo Complejo de Desarrollo, estos casos podrian ser considerados dentro de un complejo malformativo de amplio espectro y expresividad variable. El descubrimiento de los defectos integrantes de la asociacion VATER deberia conducir a la investigacion de la posible presencia de SHF
Assuntos
Recém-Nascido , Humanos , Feminino , Anormalidades Múltiplas , Transtornos do Desenvolvimento SexualRESUMO
Presentamos una paciente con asociacion VATER y seudohermafroditismo femenino (SHF) probablemente "no adrenal". Se describen 6 pacientes con estas caracteristicas referidas en la literatura (tabla 1).Sobre la base del clasico concepto en Embiologia de Campo Complejo de Desarrollo, estos casos podrian ser considerados dentro de un complejo malformativo de amplio espectro y expresividad variable. El descubrimiento de los defectos integrantes de la asociacion VATER deberia conducir a la investigacion de la posible presencia de SHF
